This site documents scientific links between vaccines and neurological disorders, including: alterations to the nervous system, autism, demyelination, seizures, convulsions, epilepsy, brain swelling, and other neurological complications.
400 Critical Vaccine Studies
Vaccines and Nervous System Changes:
- Bondarev, VN et al, "The Changes
of the Nervous System in Children After Vaccination",
Pediatria, Jun 1969; 48:20-24.
- Ehrengut W, "Central
nervous sequelae of vaccinations," Lancet 1986 May 31;1(8492):1275-1276.
- Provvidenza, G et al, [On a Case of
Benign Acute Cerebellar Ataxia in Childhood], Arch Ital Sci
Med Trop, 43:189-194, Apr 1962.
- Katsilambros, L, "[The Phenomenom
of Apathy in Man and Animals After the Injection of Viruses in
Very High Doses. Clinical Data]", Rev Med Moyen Orient,
20:539-546, Nov - Dec 1963.
Vaccines and Autism:
- Eggers, C, "Autistic Syndrome
(Kanner) And Vaccinations against Smallpox", Klin Paediatr,
Mar 1976, 188(2):172-180.
- Kiln MR, "Autism,
inflammatory bowel disease, and MMR vaccine." Lancet 1998
May 2;351(9112):1358.
- Selway, "MMR vaccination
and autism 1998. Medical practitioners need to give more than
reassurance." BMJ 1998 Jun 13;316(7147):1824.
- Nicoll A, Elliman D, Ross
E, "MMR vaccination and autism 1998," MJ
1998 Mar 7;316(7133):715-716.
- Lindley K J, Milla PJ,
"Autism, inflammatory bowel disease, and MMR vaccine."Lancet
1998 Mar 21;351(9106):907-908.
- Bedford H, et al, "Autism,
inflammatory bowel disease, and MMR vaccine." Lancet 1998
Mar 21;351(9106):907.
- Vijendra K. Singh, Sheren X. Lin, and
Victor C. Yang, "Serological Association of Measles Virus and Human
Herpesvirus-6 with Brain Autoantibodies in Autism," Clinical
Immunology and Immunopathology, Oct 1998, Vol. 89, No. 1, p 105-108.
["None of the autistic children in the study had measles in the
past, but all had the MMR" stated David Whalgren.
Vaccines and Demyelination:
- Herroelen, L et al, "Central-Nervous-System
Demyelination After Immunization with Recombinant Hepatitis B
Vaccine", Lancet, Nov 9, 1991, 338(8776):1174-1175.
- Kaplanski G, Retornaz F, Durand J, Soubeyrand
J, "Central nervous system demyelination after vaccination
against hepatitis B and HLA haplotype." J Neurol Neurosurg Psychiatry
1995 Jun; 58(6):758-759.
- Matyszak MK, Perry VH, "Demyelination
in the central nervous system following a delayed-type hypersensitivity
response to bacillus Calmette-Guerin." Neuroscience 1995
Feb;64(4):967-977.
- Tornatore CS, Richert JR,
"CNS demyelination associated with diploid cell rabies vaccine."
Lancet 1990 Jun 2;335(8701):1346-1347.
- Adams, JM et al, "Neuromyelitis
Optica: Severe Demyelination Occurring Years After Primary Smallpox
Vaccinations", Rev Roum Neurol, 1973, 10:227-231.
- In 1988, Dietrich used MRI to show that
developmentally delayed children had alterations in their myelin. Coulter
described that central nervous system damage can be exhibited as abnormal
behavior of the child. In 1935, Thomas Rivers, experimental allergic
encephalitis (EAE) can be the result of a viral or bacterial infection
of the nervous system. "The fact of the matter is that it is a
matter of record that it was known that vaccination produced encephalitis
since 1926." The authors stated, "In regions in which there
is no organized vaccination of the population, general paralysis is
rare. ... It is impossible to deny a connection between vaccinations
and the encephalitis (brain damage) which follows it." Vaccines
have been linked to seizures, convulsions and epilepsy.
Vaccines and Seizures:
- Hirtz DG, Nelson KB, Ellenberg J H,
"Seizures following childhood immunizations",
Pediatr 1983 Jan; 102(1):14-18.
- Cherry JD, Holtzman AE, Shields
WD, Buch D, Nielsen, "Pertussis immunization and characteristics
related to first seizures in infants and children,"J
Pediatr 1993 Jun;122(6):900-903.
- Coplan J, "Seizures
following immunizations," J Pediatr 1983 Sep;103(3):496.
- Barkin RM, Jabhour JT, Samuelson
J S, "Immunizations, seizures, and subsequent evaluation,"
JAMA 1987 Jul 10;258(2):201.
- Griffin MR, et al, "Risk of seizures
after measles-mumps-rubella immunization," Pediatrics 1991
Nov;88(5):881-885.
- Griffin MR, et al, "Risk
of seizures and encephalopathy after immunization with the diphtheria-tetanus-pertussis
vaccine," JAMA 1990 Mar 23-30;263(12):1641-1645.
- Cizewska S, Huber Z, Sluzewski
W, "[Prophylactic inoculations and seizure activity
in the EEG]," Neurol Neurochir Pol 1981 Sep-Dec;15(5-6):553-557.
[Article in Polish]
- Huttenlocher PR, Hapke RJ,
"A follow-up study of intractable seizures in childhood."
Ann Neurol 1990 Nov; 28(5):699-705.
- Blumberg DA, "Severe reactions
associated with diphtheria-tetanus-pertussis vaccine: detailed study
of children with seizures, hypotonic-hypo-responsive episodes,
high fevers, and persistent crying."Pediatrics 1993 Jun;
91(6):1158-1165.
Vaccines and Convulsions:
- Prensky AL, et al, "History of
convulsions and use of pertussis vaccine," J Pediatr
1985 Aug; 107(2):244-255.
- Baraff LJ, "Infants and
children with convulsions and hypotonic-hypo-responsive episodes
following diphtheria-tetanus-pertussis immunization: follow-up evaluation,"
Pediatrics 1988 Jun; 81(6):789-794.
- Jacobson V, "Relationship of pertussis
immunization to the onset of epilepsy, febrile convulsions and
central nervous system infections: a retrospective epidemiologic study,"
Tokai J Exp Clin Med 1988;13 Suppl: 137-142.
- Cupic V,et al, "[Role of DTP vaccine
in the convulsive syndromes in children]," Lijec Vjesn
1978 Jun; 100(6):345-348. [Article in Serbo-Croatian (Roman)]
- Pokrovskaia NIa, "[Convulsive
syndrome in DPT vaccination (a clinico-experimental study)]," Pediatriia
1983 May;(5):37-39. [Article in Russian]
Vaccines and Epilepsy:
- Ballerini, Ricci, B, et al, "On
Neurological Complications of Vaccination, With Special Reference to
Epileptic Syndromes," Riv Neurol, Jul-Aug 1973, 43:254-258.
- Wolf SM, Forsythe A, "Epilepsy
and mental retardation following febrile seizures in childhood,"
Acta Paediatr Scand 1989 Mar;78(2):291-295.
Vaccines and Brain Swelling:
-
Iwasa, S et al, "Swelling
of the Brain in Mice Caused by Pertussis ... Quantitative Determination
and the Responsibility of the Vaccine", Jpn J Med Sci Biol,
1985 , 38(2):53-65.
-
Mathur R, Kumari S,
"Bulging fontanel following triple vaccine." Indian
Pediatr 1981 Jun;18(6):417-418.
-
Barry W, Lenney W, Hatcher
G, "Bulging fontanelles in infants without meningitis."
Arch Dis Child 1989 Apr;64(4):635-636.
-
Shendurnikar N, "Bulging
fontanel following DPT" Indian Pediatr 1986 Nov;23(11):960.
-
Gross TP, Milstien JB, Kuritsky
JN, "Bulging fontanelle after immunization with diphtheria-tetanus-pertussis
vaccine and diphtheria-tetanus vaccine." J Pediatr 1989
Mar;114(3):423-425.
-
Jacob J, Mannino F, "Increased
intracranial pressure after diphtheria, tetanus, and pertussis
immunization." Am J Dis
Child 1979 Feb;133(2):217-218.
- Dugmore, WN, "Bilateral Oedema
at the Posterior Pole. Hypersensitivity Reaction to Alavac P injection."
Br J Ophthalmol, Dec 1972, 55:848-849.
Vaccines and Neurological Damage
-
Nedar P R, and Warren, R J, "Reported
Neurological Disorders Following Live Measles Vaccine",
1968, Ped, 41:997-1001.
-
Paradiso, G et al, "Multifocal
Demyelinating Neuropathy after Tetanus Vaccine", Medicina
(B Aires), 1990, 50(1):52-54.
-
Landrigan, PJ, Whitte, J, "Neurologic
Disorders Following Live Measles-virus Vaccination", JAMA,
Mar 26, 1973, v223(13):1459-1462.
-
Turnbull, H M, "Encephalomyelitis
Following Vaccination", Brit Jour Exper Path, 7:181, 1926.
-
Kulenkampff, M et al, "Neurological
Complications of Pertussis Inoculation", Arch Dis Child,
1974, 49:46.
-
Strom, J, "Further Experience
of Reactions, Especially of a Cerebral Nature in Conjunction
with Triple Vaccination", Brit Med Jour, 1967, 4:320-323.
-
Berg, J M, "Neurological Complications
of Pertussis Immunization," Brit Med Jour, July 5,1958;
p 24.
-
Bondarev, VN et al, "The Changes
of the Nervous System in Children After Vaccination", Pediatria,
Jun 1969; 48:20-24.
-
Badalian, LO, "Vaccinal Lesions
of the Nervous System in Children," Vop Okhr Materin Dets,
Dec 1959, 13:54-59
-
Lorentz, IT, et al, "Post-Vaccinal
Sensory Polyneuropathy with Myoclonus", Proc Aust Ass
Neurol, 1969, 6:81-86.
-
Trump, R C, White, T R, "Cerebellar
Ataxia Presumed Due To Live Attenuated Measles Virus Vaccine,"
JAMA, 1967, 199:165-166.
-
Allerdist, H, "Neurological
Complications Following Measles Vaccination", Inter Symp,
Brussels, 1978, Development Biol Std, Vol 43, 259-264.
-
Finley, K H, "Pathogenesis of
Encephalitis Occurring With Vaccination, Variola and Measles,
Arch Neur and Psychologist, 1938; 39:1047-1054.
-
Froissart, M et al, "Acute Meningoencephalitis
Immediately after an Influenza Vaccination", Lille Med,
Oct 1978, 23(8):548-551.
-
Pokrovskaia, Nia, et al, "Neurological
Complications in Children From Smallpox Vaccination", Pediatriia,
Dec 1978, (12):45-49.
-
Allerdist, H, "Neurological
Complications Following Measles Virus Vaccination. Evaluation of the
Cases seen Between 1971-1977", Monatsschr Kinderheilkd,
Jan 1979, 127(1): 23-28.
-
Ehrengut, W et al, "On Convulsive
Reactions Following Oral vaccination Against Polio", Klin
Paediatr, May 1979, 191(3):261-270.
-
Naumova, R P, et al, "Encephalitis
Developing After Vaccination without a Local Skin Reaction",
Vrach Delo, Jul 1979, (7):114-115.
-
Goswamy, BM, "Neurological
Complications After Smallpox Vaccination", J Ass Phys India,
Jan 1969, 17:41-43.
-
Schchelkunov, SN et al, "The Role
of Viruses in the Induction of Allergic Encephalomyelitis,"
Dokl Akad Nauk SSSR, 1990,315(1):252-255. [Vaccines contain
viruses, too]
-
Walker AM, "Neurologic
events following diphtheria-tetanus-pertussis immunization,"
Pediatrics 1988 Mar;81(3):345-349.
-
Shields WD, et al, "Relationship
of pertussis immunization to the onset of neurologic disorders:
a retrospective epidemiologic study," J Pediatr 1988 Nov;
113(5):801-805.
-
Wilson J, "Proceedings:
Neurological complications of DPT inoculation in infancy,"
Arch Dis Child 1973 Oct; 48(10):829-830.
-
Iakunin IuA, "[Nervous system
complications in children after preventive vaccinations],"
Pediatriia 1968 Nov; 47(11):19-26. [Article in Russian]
-
Greco D, et al, "Case-control
study on encephalopathy associated with diphtheria-tetanus
immunization in Campania, Italy," Bull World Health Organ
1985;63(5):919-925.
-
Ehrengut W at Institute of Vaccinology
and Virology, Hamburg, Germany states, "Bias in the evaluation
of CNS complications following pertussis immunization are the following:
1) Notifications of post-immunization adverse events, 2) Publications
by vaccine producers on the frequency of adverse reactions, 3) Comparison
of permanent brain damage after DPT and DT immunization, 4) Pro-immunization,
5) Immunization associated viral encephalitis, 6) Accuracy of statistics,
7) Personal. A review of these points indicates an underestimation
of CNS complications after pertussis immunization."
-
Reference: Ehrengut W, "Bias
in evaluating CNS complications following pertussis immunization."
Acta Paediatr Jpn, 1991 Aug; 33(4):421-427.
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